Phentramin-D Review

Phentramin-D Review: Does It Really Work?

Written By : Dr Ruby Shah   ✓ Fact Checked

Phentramin-D is a weight loss pill supposedly helping users lose weight quickly without dangerous side effects.

(Last Updated on June 16, 2024)

Losing weight is easier for some than it is for others.

Factors such as genetics, work schedules, slow metabolisms, access to healthy food and time to exercise can make or break the process, despite your best efforts.

To help the process along, you may need a supplement to bridge the gap between your efforts and your results.

Phentramin-D is self-proclaimed to be the “most powerful weight loss 1 pill available on the market today”.

It promises to boost the metabolism, give you abundant energy, suppress cravings, and help your body to churn through fat.

Our Phentramin-D review covers everything you need to know, including ingredients, side effects, usage, price, and the experience of real customers.

Is Phentramin-D your answer to successful weight loss, or should you steer clear?

What Is Phentramin-D?

Phentramin-D is made by the company Lazarus Labs, a US company that launched in 2003.

They create products designed to help with weight loss, sleep, anxiety, and overall wellness.

In 2007, they released Phentramin-D, describing it as not an herbal supplement, but a “scientifically developed dietary supplement”.

Phentramin-D is a weight loss supplement intended to boost the process by curbing the appetite, boosting metabolism 2
, providing extra energy, and helping to burn extra fat.

It’s certainly a stimulant, containing caffeine and synephrine (which acts similarly to stimulants).

Phentramin-D is said to be an alternative to phentermine (banned in the UK), a popular weight-loss drug that suppresses the appetite.

Phentermine is a prescription pill and cannot be bought over the counter for casual usage.

Phentermine is an effective weight loss drug but can cause anxiety, a racing heart, and dizziness.

Phentramin-D Ingredients

Phentramin-D pills

Phentramin-D is made of a proprietary blend of ingredients, with a collective amount of 222 mg.

However, there are no amounts listed for each individual ingredient, which is a little iffy considering some of them are controversial.

PEA (Phenylethylamine Hydrochloride)

PEA is made in the body, so it’s a familiar substance to our system.

PEA can also be man-made to be used for various purposes such as treating depression and low mood because it tells the body to release dopamine, which also suppresses the appetite.

PEA is a stimulant and is similar to amphetamine, which explains why it can boost concentration, focus, and help with motivation.

However, research to back the effectiveness of PEA on weight loss and other uses is limited.

1, 3, 7 Trimethylxanthine

This is simply caffeine 3, but expressed with the scientific name.

Caffeine boosts energy levels and focus for small periods, and it may also increase calorie burning via thermogenesis.

Caffeine can also curb the appetite and help with reducing food intake for an overall calorie deficit.

Hordenine Hydrochloride

Hordenine 4 can be found in natural sources such as barley and algae.

It is similar to bitter orange (see below, a controversial ingredient), and might help with weight loss.

It said to do this by telling the brain to release norepinephrine to give the body an energy boost.

However, the research is lacking and it’s unclear how effective it truly is as most tests have been done on animals.

Synephrine Hydrochloride

Synephrine 5 (bitter orange) is a stimulant similar to ephedra which is now banned because of its worrisome effect on the human heart.

Synephrine is banned by the National Collegiate Athletic Association.

Like other ingredients in Phentramin-D, research and proof that synephrine is effective for weight loss are lacking.

How Does Phentramin-D Work?

  • Phentramin-D works by suppressing the appetite by the use of caffeine, and by triggering dopamine release thanks to PEA. The reduced calorie intake due to loss of appetite is one of the leading ways Phentramin-D boosts weight loss.
  • Hordenine triggers the release of norepinephrine to give you a boost of energy and focus for better workouts and overall increased activity.
  • Caffeine boosts metabolism and fat burning even when resting.
  • Synephrine also boosts metabolism and increases fat burning.
  • The kick of energy and focus may increase exercise intensity and regularity, as well as increasing overall movement and calorie-burn throughout the day.

Phentramin-D Benefits

  • Reduces appetite and curbs cravings.
  • Helps to maintain a calorie deficit.
  • Boosts energy levels and productivity.

How To Use Phentramin-D?

Lazarus Labs recommends taking 1 pill 30 minutes before breakfast, and another before lunch.

They also recommend refraining from taking Phentramin-D in the afternoon or evening as it can mess with your sleep pattern.

As you may expect from the ingredients list, Phentramin-D should not be taken by pregnant or breastfeeding women, or people with diabetes, high blood pressure, heart disorders, or hyperthyroidism.

It should also be avoided if you are taking other medications until after you get the all-clear from your doctor.

Lazarus Labs directs customers to take Phentramin-D for no longer than 8 weeks at a time, with a 2-week break in between.

This demonstrates that this is not a life-long dietary supplement but a quick fix.

Phentramin-D Side Effects

Phentramin-D contains some pretty serious ingredients, which is why it’s recommended to be avoided after midday and must be cycled with a 2-week break in between.

Unsurprisingly, there are side-effects to be aware of due to the presence of caffeine, synephrine, and hordenine.

Side-effects may include:

  • High blood pressure.
  • Sleeplessness.
  • Anxiety.
  • Jitters.
  • Racing heart.
  • Headaches or migraines.

Is Phentramin-D A Scam?

Phentramin-D isn’t a scam, but it’s certainly not glowing.

Lazarus Labs discloses their ingredients (but not individual amounts), and are open about the potential side-effects when you read the small print.

However, they are a little tricky here and there, such as not clearly disclosing caffeine on the ingredients list.

They offer what they claim to, but whether or not it’s something you should use is another question.

Phentramin-D Reviews & Complaints

Phentramin-D bottlesIt’s hard to find reviews of Phentramin-D outside of their website.

Most of the reviews on the site are 4 or 5 stars, with a few 1’s and 2’s.

The positive reviews have a recurring theme of the reviewer looking for very fast weight loss and achieving it by heavily reducing their food intake.

What’s more, many of the positive reviews mention that the reviewer was looking for an alternative to Phentermine which they had taken previously.

“I was desperate to find something to help but really didn’t have much hope that this would work and thought I was probably throwing away money. In 7 weeks I have lost 25lbs. The first day I took it I was very dizzy but went ahead and tried it the 2nd day and my body had already adjusted to it and there has been no more dizzy feeling. I still want to lose another 25lbs to be 125lbs again and with this product I think I am going to make it to my goal.”

“I’ve been taking Phentramin-D for three days now. I have to say that my appetite has significantly decreased! I have to force myself to eat and it gives me a great energy boost. The only unpleasant side effects are extreme dry mouth and after a while the energy wears off and I crash. But I’m thinking it’s because I’m barely eating anything. Going to start drinking protein drinks and see if that helps. But overall I love it!”

The negative reviews are mostly based around a lack of effect, or experiencing side-effects:

“The most significant effect I had from the pill was the anxiety.”

“I wasted money on these and they do nothing except give me a raging headache. They are nothing compared to the “real” phentermine. Don’t waste your money. If you are looking for phentermine, go get the real stuff.”

Phentramin-D: Packages, Prices & Where To Buy It

You can buy Phentramin-D from the Lazarus Labs site and it will set you back a significant $67 for one bottle (60 tabs, a 30-day supply).

If you buy more than one bottle, a small discount applies (for example, 5% for 2 bottles, and 27% off for 9 bottles).

Lazarus Labs offers free US and international shipping.

Money Back Guarantee

Lazarus Labs offers a money-back guarantee, with a few caveats.

You can send the product back within 30 days of the order date, and you will get a partial refund.

You must pay for the shipping cost, and Lazarus Labs subtracts sales tax plus $10.95 (per bottle).

This is an okay deal, but it’s not as generous as other supplement brands, that’s for sure.

See below how the official site looks like.

Phentramin-D Official Website

Phentramin-D Pros & Cons


  • Boosts energy levels.
  • Suppresses appetite and cravings.
  • Increases focus.
  • Simple to take.


  • May disrupt sleep.
  • Caffeine is not clearly stated on the label (uses scientific name instead).
  • Contains synephrine (bitter orange).
  • No full refund.
  • Risk of significant side effects.
  • Expensive.
  • Lack of research.

Phentramin-D Review: Final Verdict

Phentramin-D bottlePhentramin-D may lead to weight loss and fast weight loss at that, but we are reluctant to recommend it because of the potential side-effects.

Anything that disrupts sleep, raises the heart rate and blood pressure and causes anxiety isn’t worth the speedy weight loss.

You would be better off losing weight at a slower rate while maintaining a healthy heart and overall well being.

What’s more, it’s easier to maintain weight loss that was done slowly and healthily.

While a calorie deficit is crucial for weight loss, completely losing your appetite and forgetting to eat is not so great.

When you eventually stop taking the supplement, you may go back to your old way of eating without having learned any life-long diet and lifestyle habits.

The weight will likely come piling back, sparking the cycle to begin again.

Before taking Phentramin-D, talk to your doctor first as they may have a better and safer alternative.

We laid out the facts, will you buy Phentramin-D? Comment below and tell us what you think!

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