joint pain treatment supplements

4 Best Supplements To Treat A Joint Pain And Arthritis

Written By : David J. Grossklaus   ✓ Fact Checked

MyPill have done the research and put together an extensive comparison of the 4 best joint pain supplements you can buy right now.

(Last Updated on December 12, 2022)

It’s no secret that as we age, our bodies do begin to decline physically.

It’s an unfortunate fact of life, however it’s one that through proper care and appropriate supplementation, we can significantly reduce.

As we age, certain parts of our body degrade a little faster than others.

And if you have lead a relatively active life, theres a good chance that the part which will degrade the fastest will be the joints.

Joint’s can break down over time from a whole host of reasons, and often the experience is unpleasant to say the least, with degenerative changes causing pain and reduced mobility.

However, we are firm believers that joint health should be a preventative measure rather than a reactive measure.

So rather than waiting until your joints are in significant pain, we recommend beginning preventive measures from the moment you begin to notice and minor niggles or joint discomfort.

And one of the best preventative measures you can incorporate into your daily routine to increase joint health, is a well dosed joint health supplement.

Best joint health supplements are designed to be convenient and effective in providing fast relief on joint pain.

Most joint supplements include essential ingredients such as glucosamine, chondroitin, and collagen peptides.

Ingredients such as these help the joints to function properly, make your joints hydrated by helping your cartilages to keep retain water, enhance the synthesis of collagen and work as anti-inflammatory too.

Overall, these supplements are designed to increase the health of your joints, providing pain relief, and allowing you to get back to living you life again.

As with any supplement category, there are simply too many joint supplements on the market nowadays which simply don’t work as effectively as what they claim.

For this reason we have done the research for you, and found joint supplements that actually work.

Here are the Top 4 Joint Health Supplements.

Ranking: Best Supplements To Support Joint Health

ProJoint Plus


Performance Lab Flex


Ingredients Quality




Product Effectiveness




Brand Reputation




1. ProJoint Plus

ProJoint Plus

ProJoint Plus is a dietary supplement made from herbal extracts designed to improve joint health, support, and flexibility.

Specifically, it helps to keep the joint cartilage healthy while maintaining their mobility and flexibility.

This supplement is made from natural ingredients that have been scientifically proven to work.

It is also backed by professional opinions from various quarters, including Harvard Medical School, Healthline, and the Arthritis Foundation.

You do not require a prescription to purchase ProJoint.

For best results, the manufacturer recommends that you take three tablets per day with a meal.

Although results vary with individuals, you are likely to experience effects within a few days.

ProJoint is manufactured by Vita Balance Inc., a company located in Virginia, United States.

It is available from the official website and ships worldwide to 23 countries.

How it works?

ProJoint relies on a combination of ingredients to bring you the following benefits:

  • Cartilage health – Cartilage is the rubbery material covering bone joints. It acts as a cushion, absorbing shock and easing friction in the joints. Damage to cartilage can lead to joint pain, stiffness, and inflammation. ProJoint helps to keep it healthy and functional.
  • Joint health – If you live an active lifestyle such as that of sports, you might easily injure your joints. Taking ProJoint can boost quick recovery as well as the healthy maintenance of bones.
  • Joint mobility – This is the ability of joints to move as they should. Due to various reasons, joints may become stiff, making mobility difficult. Stiff joints can also cause pain and restrain movement. ProJoint is made to promote joint mobility.


Here are the three top ingredients found in this joint pain supplement that make it so effective:

  • Glucosamine Sulfate – This ingredient is common in most joint pain supplements. It is a natural sugar that is found in cartilage. In supplements, Glucosamine Sulfate is extracted from shellfish. It has been seen to ease joint pain and repair broken cartilage 1.
  • Quercetin – Quercetin is a pigment found in many plants and foods. It has numerous health uses and has been used to treat hay fever, cataracts, asthma, and gout among others. Because it is also an antioxidant, it is used in this formula to fight free radicals and oxidants associated with aging that puts strains on joints and bones.
  • Boswellia Extract – Boswellia is a herb native in India, where it is has been used as medicine for hundreds of years. It is an effective anti-inflammatory and is therefore useful in easing joint pain and inflammation.


  • Made from natural ingredients.
  • Endorsed by respectable professionals.
  • Improves cartilage health and joint mobility.


  • Only available on the official website.
  • Independent reviews are not available.

2. ProFlexen


Joint pain is most often caused by over-burdening of the cartilage and surrounding tissues.

This can be brought about by strenuous sports activities, standing for long hours, living a sedentary lifestyle, and obesity.

ProFlexen is a dietary supplement that promises to restore and protect joint health.

Specifically, it helps with free movement of joints, strengthens bones and boosts the production of collagen and protects joints during strenuous activity.

It is made from natural ingredients whose effectiveness is backed by two clinical trials.

For best results, it is recommended that you take two capsules per day.

ProFlexen is made in the United Arab Emirates by Key Player Ltd, a company that manufactures health and beauty products.

It ships worldwide and offers a money-back guarantee for unhappy customers.

How it works?

ProFlexen relies on a potent formula to deliver its promises.

The secret behind this formula is UC-II, a patented collagen 2 ingredient that has been seen to be quite useful in joint health.

Its effectiveness was proven by two double-blind studies conducted on human volunteers.

One of the groups comprised of prophylactic users, while the other comprised of people with degenerative joint disease.

This study found that UC-II is more effective than two of the most common joint pain ingredients, glucosamine, and chondroitin.

Other than UC-II, the ProFlexen formula consists of ingredients that complement each other to strengthen bones, prevent joint stiffness, and protect joints during physical activity.


Here are the three top ingredients found in this joint pain supplement that make it so effective:

  • Boswellia Serrata Resin Extract – This is an Indian herb that is used in this formula for its ability to improve and relax joints. It contains acids that enhance joint flexibility. Additionally, it treats inflammations in the joints and eases the pain.
  • Curcuma Longa Rhizomes Extract – This is a herb related to the ginger family, also found in India. It has anti-oxidant and anti-inflammatory properties that help alleviate joint inflammation and soreness.
  • Vitamin C – Vitamin C is essential in the production of collagen, which is a significant component in connective tissue. Because joints contain big amounts of collagen, a deficiency of vitamin C can affect them negatively. ProFlexen provides a good dose of vitamin C ensuring optimal function 3.


  • Contains clinically proven ingredients.
  • Made from natural ingredients.
  • Can be used by people of all ages.
  • Offers a money-back guarantee.
  • Has no side effects.


  • Manufacturer information is not readily available.
  • Has no independent reviews.
  • Only available on the official website.

3. Performance Lab Flex

Performance Lab Flex

Performance Lab Flex is a dietary supplement that supports flexibility, comfort, and overall joint health.

Specifically, it provides joint lubrication and enhances shock absorption.

It also supports the health and flexibility of ligaments, tendons, and cartilage.

This supplement is especially useful for people who lead active lifestyles that may lead to joint aches.

This could be strength training, excessive typing, long-distance running, or jobs that entail repetitive joint movements.

It is also ideal for adults over the age of 55, as they may be more susceptible to joint aches.

Flex is formulated from clean, vegan ingredients that are free from synthetics that might be hard on the stomach.

It is also safe to use every day in the long term as it uses the minimum effective dosage to ensure tolerability.

For the best results, the manufacturer recommends that you take two capsules daily with plenty of water.

To soothe any occurring joint pain, you may take another two capsules immediately following physical activity.

Performance Lab Flex is manufactured by Opti Nutra, a health and sports supplement company based in the United Kingdom.

It is available for purchase from the official website

Performance Lab Flex ships worldwide, and the manufacturer offers free shipping for orders over $100.

How it works?

Performance Lab Flex uses its clinically tested ingredients to support joint health through several key pathways.

  • Protection: It protects joints from oxidative damage caused by free radicals and destructive enzymes.
  • Lubrication: This supplement supports the creation of synovial fluid, which is crucial for joint lubrication and flexibility.
  • Shock absorption: It helps in the regeneration and hydration of cartilage, which helps to keep it thick and healthy.
  • Bone health: Having healthy joints relies on strong, mineral-dense bones, which Flex supports.
  • Resilience: This supplement keeps ligaments nourished and aids their repair for continued functionality.
  • Comfort: Flex boosts overall immunity in the body, something that connective tissues greatly benefit from.


Here are the three main ingredients in this joint pain supplement that make it so effective:

  • Boswellia Serrata: Boswellia Serrata is a desert tree that produces a gum-like substance that contains active acids that are effective in joint health. These acids improve immune response, which soothes joints, blocks an enzyme that eats away at joint cartilage and inhibits enzymes that weaken connective tissue.
  • Curcumin: Curcumin is the ingredient that gives turmeric its yellow color. It is a potent anti-inflammatory and antioxidant that protects joints from oxidative stress. It also protects cartilage from destructive enzymes and supports the production of collagen, the protein that gives structure to bones, tendons, ligaments, and muscles.
  • Glucosamine Sulfate: This is a natural sugar found in cartilage, ligaments, tendons, and even in synovial fluid. It plays an important role in the formation of proteins that form connective tissues found in joints. It also supports cells that aid in the repair and regeneration of cartilage.


  • Contains proven ingredients.
  • Suitable for vegans and vegetarians.
  • Does not contain caffeine.
  • Contains ingredients that help with rapid absorption.


  • Not available in stores.

4. Flexidium 400

flexidium 400

As we grow older, our bodies produce less and less collagen, a substance that is the building block of cartilage.

Cartilage is the rubbery like material found between a joint that works as a cushion, preventing friction.

With time, the cartilage in our bones develops cavities, which cause increased friction and pain during movement.

This situation is exacerbated by other factors such as obesity, lack of physical activity, and contusions.

Flexidium 400 is a dietary supplement that was designed to address this and other joint problems.

It is ideal for people who suffer from recurring joint pain and stiffness and those who want to improve joint function.

This supplement is made from carefully selected natural ingredients that have been clinically proven to give results.

It can also be taken by people who do not have joint pains as yet, but would like to take preventive measures.

For the best results, it is recommended that you take two capsules per day with a glass of water.

Flexidium 400 is manufactured in an FDA approved lab in the USA and ships worldwide.

How it works?

Flexidium 400 works by targeting the overall wellbeing of joints by:

  • Replacing depleted collagen in the joints.
  • Maintaining proper joint conditions by providing Zinc.
  • Preventing joint degradation by use of Selenium.
  • Replacing depleted hyaluronic acid in the synovial fluid, ensuring fluid joint movement.


Here are the three top ingredients found in this joint pain supplement that make it so effective:

  • Collagen – Collagen is an essential protein found in connective tissues that make up body parts, including joints. It is responsible for joint regeneration and helps ease the pain. The collagen used in this supplement is extracted from shellfish and is quite similar to human collagen. It is also more easily absorbed than other types, such as beef or pork.
  • Hyaluronic Acid – Hyaluronic acid is a critical component in synovial fluid, the thick substance that acts as a lubricant allowing joints to glide over each other. When this component breaks down, such as in cases of osteoarthritis, it results in joint pain and stiffness. Flexidium 400 contains a good amount of hyaluronic acid which can help restore the balance 4.
  • L- Ascorbic Acid – Vitamin C is a crucial requirement when it comes to the building of collagen, the building block of cartilage. It is also an antioxidant that fights free radicals preventing the damage and degeneration of cartilage.


  • Made from natural ingredients.
  • Cures and also prevents future joint pains.
  • Has no side effects.
  • Ships worldwide.


  • Manufacturer information is scanty.
  • Available only on the official website.
  • Has no money back guarantee.

FAQ (Frequently Asked Questions)

What is a joint pain supplement?

A joint pain supplement is any kind of dietary supplement that is made to ease joint pain, repairing joint damage or enhancing joint function.

There are numerous types of joint supplements each with a different focus, but ultimately, all aim to address joint pain management.

What are some of the benefits of joint pain supplements?

Joint pain supplements have the following benefits:

  • They ease joint pain.
  • They enhance joint mobility and flexibility.
  • They repair cartilage damage in the joints.
  • They strengthen bones.
  • They protect joints against degradation.
  • Promote joint health and function in the long term.

Who should use joint pain supplements?

Joint pain supplements can be used by:

  • People who suffer from joint pain and stiffness.
  • People who want to enhance joint functionality.
  • Those who suddenly find it difficult to do things that require much movement.
  • Those that want to regain physical capabilities after surgery or an accident.
  • Those who wish to safeguard joint health to prevent future problems.
  • People who are losing collagen and experiencing joint pain as a result of age.

Which ingredients should I expect to see in a joint pain supplement?

The ingredients in a joint pain supplements will vary from maker to maker, but there are some standard ingredients that we expect to see in the most effective supplements.

Some of the most prominent include:

  • Collagen.
  • Chondroitin.
  • L- Ascorbic Acid.
  • Glucosamine Sulphate.
  • Flaxseed oil.
  • Bromelain.
  • Turmeric.
  • Boswellia Extract.
  • Quercetin.
  • Curcuma Longa Rhizome Extract.

How can I decide which joint pain supplement to use?

  • Needs – There are many joint supplements available in the market today. The best way to choose one is to evaluate several and pick the one that meets your needs the most. Some supplements are dedicated to easing joint pain, others to building collagen, etc.
  • Ingredients – The other factor that you should consider in a supplement is the type of ingredients used. There are specific ingredients that are common in joint pain supplements. You should ensure that the supplement you pick has some of these or other effective ingredients.
  • Ingredient quantity is also important as it can tell you how effective the supplement is. Having many ingredients in a supplement does not in any way imply that it is more effective than one with fewer ingredients.
  • Price – You should ensure that you are getting value for money by comparing the supplement quantity and type of ingredients with other similar products.

What are the side effects of joint pain supplements?

As with many other dietary supplements, joint pain supplements are made from natural ingredients and will not have any adverse side effects.

Most do not contain artificial additives and are suitable for vegans and vegetarians.

As with any medication, you should be on the lookout for common symptoms such as headache, abdominal discomfort and nausea when you start taking a supplement.

While unlikely, if you experience any side effects, you should stop taking the supplement and consult a doctor.

If you are worried about side effects, it might be wise to discuss with your doctor before you embark on taking a joint pain supplement.


Joint pain, if unchecked, can severely limit movement, not to mention the discomfort of being in constant pain.

It can also put limits on your lifestyle, preventing you from doing the things you love.

This could be working out, jogging, dancing, working, or even playing with children.

Taking a joint pain supplement can ease this pain and give you your life back.

Even where there is no direct onset of pain, it is essential to take joint pain supplements to promote joint health and prevent any future eruptions.

There are numerous joint pain supplements in the market, and picking the right one can be difficult.

This is why we have prepared this review; to give you the highlights on five of the best joint pain supplements available.

We trust that you will be able to pick one and be on your way to attaining joint health and function.

One Reply to 4 Best Supplements To Treat A Joint Pain And Arthritis

  1. Thank you for your obvious involvement in the supplement industry.
    Looks to me like you’ve done your homework. my question is why isn’t
    OMEGA XL. on your list of top five? Are the top five a better products, just as good
    or does Omega XL fall short. Is number 1 on the list the better of all listed?
    Am I falling for a sales pitch by Mr Larry King?

Leave a Reply

Your email address will not be published. Required fields are marked *


All MyPill content is medically reviewed or fact checked to ensure that it is as accurate as possible.

We have strict sourcing guidelines and only link to other reputable media sites, educational institutions, and, whenever possible, peer-reviewed studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please contact us through the feedback form on this page.