protandim review

Protandim Review: Should You Buy It?

Written By : David J. Grossklaus   ✓ Fact Checked

Protandim is a plant-based nutraceutical that contains milk thistle, bacopa, turmeric, ashwangandha, and green tea, and this combination is supposed to increase the body’s antioxidant activity. Does it really work? Read our review!

(Last Updated on November 29, 2022)

Rich in antioxidants’ you have probably come across this marketing catchphrase.

Oxidation is a normal body process but it produces free radicals that may damage the cells and lead to cancer, aging, or heart disease.

This has resulted in a booming business in dietary supplements that contain antioxidants or promise to boost the body’s antioxidant production.

Protandim Nrf2 Synergizer is one of the dietary supplements that claim to increase antioxidant activity by 40% in humans in 30 days.

Is this another marketing buzz?  What does Protandim do for you? Does Protandim nrf2 work?

Get all the facts in this Protandim Nrf2 Synergizer review.

What Is Protandim?

Protandim Nrf2 is a dietary supplement that promises to increase antioxidant production in the body. It does so with a blend of natural ingredients with potent antioxidant properties.

It is manufactured by LifeVantage Corporation, a multi-level marketing company based in Utah.

Life Vantage claims that Protandim can prevent various medical conditions including cancer, diabetes, aging, panic attacks, and memory loss.

As a result, FDA issued a warning letter in 2017 citing illegal advertising claims.

Protandim is currently promoted as an anti-aging supplement. What’s the evidence to support the claims?

Let’s go through the ingredients.


protandim supplement

Protandim is surrounded by a lot of marketing material content but you’ve got to look past that and get into the supplement facts.

We went deeper into each ingredient, and the first issue we have to point out is that Protandim Nrf2 contains a lesser dosage of each ingredient compared to the recommended daily intake.

Secondly, some ingredients require more scientific evidence to substantiate the claims.

Bacopa extract (150mg)
Bacopa is one of the essential herbs used in traditional Ayurvedic medicine to treat epilepsy, lower anxiety, and boost memory. Protandim features bacopa due to its powerful antioxidant profile. It contains bacosides –active substances that have potent antioxidant effects. Bacopa is proven to neutralize free radicals and prevent cell damage. Besides, it reduces inflammation, boosts brain function, enhances anticancer effects, lowers blood pressure, and reduces stress and anxiety.
Milk Thistle (225mg)
Milk thistle is a herb that contains substances known as silymarin (65-80%) that have high anti-inflammatory, antiviral and antioxidant properties. It helps protect the liver against damage 1, prevent age-related mental decline, protect against bone loss, offer anticancer effects, and lower sugar levels in diabetic patients.
Ashwagandha (150mg)
Ashwagandha is an adaptogen that helps the body manage stress. Also, it has antioxidant properties, a good reason why Protandim includes this herb in its formulation. It contains withanolides, antioxidants that have been proven to fight tumor growth and inflammation. Ashwagandha helps protect against cellular damage by reducing free radicals in cells.
Green tea (75mg)
Green tea has 8 to 10 times more antioxidants than fruits and vegetables. It contains polyphenols, antioxidants that fight cancer and reduce inflammation. Specifically, green contains a catechin known as epigallocatechin-3-gallate (EGCG), an antioxidant that prevents cell damage by reducing the formation of free radicals. These antioxidants lower the risk of some cancers, protect the brain from aging, may inhibit the growth of oral bacteria, and protect against heart diseases.
Turmeric (75mg)
Turmeric a herb that gives food its yellow color has been used in Asia for centuries for cooking and medicinal purposes. But it is now adopted by the west for its various health benefits. It is considered a superfood that can prevent depression, cancer, and joint pain. Turmeric contains curcumin, a compound with potent antioxidant and anti-inflammatory properties. It helps to delay aging, fight age-related chronic diseases, may help treat symptoms of arthritis, and stimulate your body’s antioxidant defense 2.

How Does Protandim Work

protandim banner

As you age, your body experiences cellular deterioration that is caused by free radicals, toxicological insults, and other oxidants.

The body fights these radicals by producing antioxidant and detoxification enzymes through Nrf2-dependent mechanisms. However, Nrf2 tends to work less effectively as we get older.

Here is where Protandim Nrf2 Synergizer comes in. It enhances the production of antioxidant and detoxification enzymes by activating the Nrf2 pathway.

Besides, it improves mitochondrial function and supports the body’s ability to repair and rejuvenate cells which promote overall health.

Here are other Protandim Nrf2 benefits to expect:

  • Lowers oxidative stress by 40% in just 30 days.
  • Maintains survival genes.
  • Lowers cellular stress through Nrf2 activation.
  • Promotes optimal cell function by detoxifying the cells.
  • Produces antioxidant enzymes that neutralize more than 1 million free radicals.

How To Use It?

You should take one caplet of Protandim Nrf2 daily with food.

Consult a physician if you are on immunosuppressive therapy, nursing, or pregnant before taking Protandim.

Are There Any Side Effects?

protandim bottles

Do not worry, Protandim Nrf2 Synergizer appears safe and well-tolerated by users. We did not find any reported side effects.

However, the manufacturer warns that you may experience allergic responses from one of the ingredients such as headaches, gastrointestinal disturbances, and rash on the hands and feet.

The symptoms disappear if you discontinue use.

Is Protandim A Scam?

Protandim Nrf2 Synergizer is not a scam but we have a few concerns.

It had one recall due to metal contamination. In 2012, LifeVantage made a voluntary recall of Protandim Nrf2 Synergizer due to the potential inclusion of metal fragments in the final product.

Besides, there are only two human clinical studies that have been carried out in 2006 3 and the other in 2016.

The 2016 study 4 shows that Protandim Nrf2 Synergizer did not raise antioxidant enzyme concentrations or affect the quality of life compared to placebo.

The other studies are animal and laboratory studies, and the current evidence is not sufficient to draw clinical recommendations.

Protandim Reviews: What People Say About This Product?

protandim pills

There are many reviews online, both favorable and unfavorable.

Of 314 customer reviews on Amazon, 71% are giving it 5 stars with an overall rating of 4.4 stars out of 5 stars.

What did users have to say?

Let’s start with the positive ones.

Lori Murray says:

I have fibromyalgia. I was in constant pain some days better than others but always there. the first month is the detox month and I didn’t feel like it was helping but my friend encourages me to continue taking it because by the end of the 3rd month I was almost pain-free. Such a difference. It gave me my life back. Won’t go without it!

Mcannie writes:

I have used Protandim for about 4 months and can see and feel the difference in my body! It helps to keep my skin clear from blemishes, but more importantly, has really helped reduce my inflammation. There are distributors everywhere if you have difficulty obtaining any elsewhere.

What about negative reviews?

Marc Hoffman is a little disappointed. He reports:

I have been taking Protandim for around 5 months. The difference in how I feel is nonexistent. I still have chronic pain, I still get chronic sinus and respiratory infections (and I’m a runner!), and I still don’t sleep well. This product has a placebo effect written all over it.

Kay adds:

I couldn’t take the vitamin because it caused problems with my other medications.

Protandim: Packages, Pricing and Where to Buy

protandim website

One bottle of Protandim Nrf2 Synergizer contains 30 caplets.

Protandim is available on the official website:

How much does it cost?

  • Protandim Nrf2 Synergizer single (one time order) : $59.99 | Subscribe & Save: $49.99
  • Protandim Nrf2 Synergizer 3-pack (one time order): $150.99 | Subscribe $ Save: $125.99

The manufacturer allows you to skip a month or cancel your subscription online at any time.

Money-Back Guarantee and Refund Policy

Protandim Nrf2 Synergizer comes with a 30-day money-back guarantee.

Pros and Cons


  • Comes with a money-back guarantee.
  • Free of wheat, gelatin, yeast, dairy, and gluten.
  • Transparent label and dosage.


  • Contains lower dosages than the recommended daily intake of each ingredient.
  • Insufficient evidence in human clinical trials.
  • Potential side effects.
  • Few human clinical trials.

Protandim Review: Should You Buy It?

Protandim makes some very bold claims but with insufficient evidence; human research does not back up the promises.

Despite the high number of studies conducted, most are animal and in-vitro studies that have created a marketing buzz.

Basically, there is no concrete evidence that Protandim promotes health or quality of life. It does not seem to treat any medical conditions.

Besides, Protandim uses very low dosages of each ingredient compared to the recommended daily intake.

There is a need for clinical proof showing that individuals who take Protandim have significant outcomes compared to the control group.

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