Osteo Bi-Flex

Osteo Bi-Flex Review: Does It Really Work?

Written By : Rohit Dwivedi, M.D.   ✓ Fact Checked

Osteo Bi-Flex is a is a joint health supplement that helps the body to deal with joint pain, arthritis, and other related problems by promoting joint fluidity and flexibility.

(Last Updated on December 1, 2023)

The Osteo Bi-Flex line is a suite of joint care supplements.

Osteo Bi-Flex Ease – in particular – is a shellfish-free formula designed to promote and enhance joint comfort.

Just one easy-to-swallow mini-tab a day nourishes your body with herbal and natural ingredients.

Or so that’s the claim.

But does the Osteo Bi-Flex proprietary formula really reduce joint pain?

Keep reading to find out.

What Is Osteo Bi-Flex?

Osteo Bi-Flex is a joint heath brand created by The Nature’s Bounty Co.

The Nature’s Bounty Co. produces innovative solutions with high-quality health and wellness products.

Based in Long Island, this nutritional supplement manufacturer is one of the largest in the United States.

The numerous brands associated with The Nature’s Bounty Co. cover a vast range of nutrition and supplement products.

Every Osteo Bi-Flex product is created with Joint-Shield. Joint-Shield is an advanced proprietary formula containing 5-Loxin, derived from the Boswellia Serrata extract. 5-Loxin is proven to reduce pain associated with occasional joint flare-ups.

Studies indicate that Osteo Bi-Flex can improve joint health within seven days.

And continued use over 90 days can lead to increased improvement.

By including UC-II (type II collagen) and vitamin D3, Osteo Bi-Flex Ease seeks to provide the exact assistance needed to reduce joint discomfort.

Unlike many joint supplement, this product doesn’t contain shellfish or gluten.

Product List

  • Osteo Bi-Flex Ease 7-Day Starter Pack: is a week-long trial amount of Osteo Bi-Flex Ease. The natural collagen and patented Joint Shield formula can deliver joint comfort within seven days. With the trial pack, you can ensure Osteo-Bi Flex Ease works for you.
  • Osteo Bi-Flex One Per Day: contains glucosamine, vitamin D and Joint Shield. Formulated to nourish damaged joints with one daily coated tablet, One Per Day is designed specifically for those with active lives.
  • Osteo Bi-Flex Joint and Muscle: combines Ester-C, CherryPure and Joint Shield. Ester-C works to enhance enzymes in collagen creation and support joint maintenance. Cherry Pure works to increase recovery and muscle support.
  • Osteo Bi-Flex Pain Relieving Cream: is a topical ointment containing menthol, glucosamine and Methyl Salicylate. This versatile cream targets relief for immediate and localized joint care.
  • Osteo Bi-Flex Triple Strength: with glucosamine, manganese, vitamin C and Joint Shield, is made for play. These tablets purportedly enhance mobility and protect joints. Triple Strength is ready when you are.
  • Osteo Bi-Flex Triple Strength + Turmeric: contains the added benefits of the antioxidant turmeric. This curcumin-containing ingredient yields powerful properties known throughout centuries for its therapeutic benefits.
  • Osteo Bi-Flex Triple Strength MSM: houses the organic sulfur compound, MSM. In conjunction with glucosamine and Joint Shield, MSM provides substantial collagen and cartilage production and protection for healthy, flexible joints.
  • Osteo Bi-Flex Triple Strength with Vitamin D: encourages healthy bone density and a strong immune system. Our bodies are complex systems that require a specific nutrient intake, and the added Vitamin D3 is perfect for many joint pain sufferers.

Osteo Bi-Flex Ingredients


Three key ingredients constitute the Osteo Bi-Flex Ease formula: Vitamin D3, Joint Shield 5-Loxin Advanced (derived from Boswellia serrata extract) and UC-II Collagen.

There are, however, numerous other ingredients that seem to serve little purpose in the formula.

Every Osteo Bi-Flex Ease tablet is free from shellfish, gluten and GMOs.

Vitamin D3

The Osteo Bi-Flex Ease formula contains 100% daily value of Vitamin D3.

Essential to bone health, Vitamin D3 may not be consumed adequately in modern diets and lifestyles.

It is found in few foods naturally.

Supplementation of this active form of Vitamin D is common and often necessary.

By assisting the absorption of calcium into the body, Vitamin D3 promotes bone density and overall bone health.

Joint Shield 5-Loxin Advanced

Joint Shield is a patented formula of 5-Loxin, a super concentrated version of Boswellia serrata.

This herbal extract is commonly called “Indian Frankincense”.

The 5-Loxin formula contains AKBA, a Boswellia acid.

The bioavailability of AKBA soars above many commercially available versions of Boswellia serrata.

Joint Shield reduce joint pain in seven days. 5-Loxin, however, is not available through food sources and must be obtained through supplementation.

UC-II Standardized Collagen

This type II collagen is natural component of the body.

Undenatured type II collagen provides elasticity where joints form.

Although oral consumption of UC-II provides increased mobility and joint comfort, the effects are not permanent.

Since UC-II is not found in food, daily supplementation is required for those receiving its joint relief properties on a continuous basis.

Other Ingredients

Calcium Carbonate, Cellulose (Plant Origin), Cellulose Coating, Vegetable Stearic Acid, Croscarmellose, Dextrose, Titanium Dioxide Color, Less than 2% of: Calcium Silicate, Magnesium Silicate, Medium Chain Triglycerides, Silica.

How Does Osteo Bi-Flex Work

how it works
Click image to see a latest prices

Osteo Bi-Flex Ease contains the propertierary formula: Joint Shield.

This patented blend contains 5-Loxin Advanced, which is extracted from the Boswellia serrata tree.

The Boswellia serrata tree – originally found in ancient India – houses the Boswellic acid AKBA. 5-Loxin Advanced contains a highly concentrated amount of AKBA.

Joint Shield was put to the test with two clinical trials.

These human studies illustrated significant improvements in joint health within one week.

Throughout the duration of the clinical studies, joint health continue to improve with constant supplementation.

To maintain joint health support, Joint Shield 5-Loxin Advanced should be taken consistently as part of a daily regimen.

How To Use It

Simply take one mini-tab a day.

Made for those with a lightly active to moderately active lifestyle.

As with any supplement regimen, make sure to eat a balanced diet and exercise.

Consult your before consuming any new supplement.

Osteo Bi-Flex Side Effects

Is It A Scam?

The scientific evidence supporting Joint Shield appears to be reliable.

Similarly, significant improvements by UC-II supplementation is scientifically grounded.

The list of other ingredients is a bit of a deterrent, but does not make it a scam.

The customer reviews also lend credibility to the product.

Just remember… it may not work for everyone.

Osteo Bi-Flex Reviews & Complaints

osteo bi-flex real users reviews

Out of 104 customer reviews on Amazon, Osteo Bi-Flex Ease receives 4 out of 5 stars.

  • An overwhelming majority (65%) gave the product 5 stars.
  • The second largest percentage (14%) awarded the supplement 4 stars.
  • 6% of reviewers gave 3 stars.
  • 5% provided 2 stars.
  • 10% bestowed a 1-star review.

ShannonOnTheLakes indicates:

I purchased these after receiving a sample size. They were so effective that I quickly replaced them with a month-long supply.It wasn’t until I ran out of my supply that I realized just how much they helped with pain levels. Those knee and hip pains came back with a vengeance. Not every supplement works for every single person, but this one has been great for me.

Janice Hardy beams:

Totally satisfied with these as they were easy to swallow. I am 81 years old and have been taking Osteo-Biflex for 35 years. I am not totally arthritis free, but I am very mobile and experience very slight pain, mostly in my hands. I credit my good mobility to this product. I will definitely order again and again!

Leslie R. Cowger shares:

I purchased these to see if they helped my pain knowing the might or might not. They did not but it does not indicate an inferior product. I had no side effects as with other products for which I am grateful.

An Amazon Shopper discusses:

I have used the “regular” Osteo Bi-Flex Triple Strength, with good results, but decided to try Ease since they were smaller and were claimed to be equally effective. They were ineffective for me and the pain returned. I have returned to the “regular” Osteo and it has again helped. I’m not sure whether the company has research to back up their claims for Ease, or if results just differ a lot from one user to the next.

Osteo Bi-Flex: Packages, Prices & Where To Buy It

  • Osteo Bi-Flex Ease 7-Day Starter Pack: $21.68
  • Osteo Bi-Flex One Per Day: $17.70
  • Osteo Bi-Flex Joint and Muscle: $25.09
  • Osteo Bi-Flex Pain Relieving Cream: $7.76
  • Osteo Bi-Flex Triple Strength: $34.46
  • Osteo Bi-Flex Triple Strength + Turmeric: $25.09
  • Osteo Bi-Flex Triple Strength MSM: $25.09
  • Osteo Bi-Flex Triple Strength with Vitamin D: $35.47

They shipping worldwide.

Prices are vary.

See below how the official site looks like.

osteo bi flex official website
Click image to see a latest prices

Return/Refund Policy

The company does not offer a money back guarantee.

Refund policies may vary depending on place of purchase.

Pros & Cons


  • Clinically proven by two human trials.
  • Easy to swallow.
  • Relatively cost-effective.


  • Excessive list of other ingredients.
  • Drastic price difference from various retailers.

Osteo Bi-Flex Review: Final Words

osteo bi-flex supplement review - verdict

All in all, the Osteo Bi-Flex products offer a range of joint health options.

Depending on your allergies, you may lean towards Osteo Bi-Flex Ease over their other products.

There is also a 7-day sample pack available, if you’d like to try it relatively risk-free.

Check with the provider supplying Osteo Bi-Flex Ease – you may be eligible for a full refund, if it doesn’t work for you.

You may find that a specialized kick in the right direction (whether it’s Vitamin D or MSM or Turmeric) may indicate out which Osteo Bi-Flex product is best for you.

We laid out the facts, will you buy Osteo Bi-Flex? Comment below and tell us what you think!

5 Replies to Osteo Bi-Flex Review: Does It Really Work?

  1. Hi I started to take this meds for my knee hope I get the results I looking for the pain in my knees I am unable to do anything.
    Thank you

  2. I am taking the Ease product for hip and knee pain.
    There seems to be enough vit D in the pill. Do I still need to take my daily Vit D I’ve been taking for years D3, 25mcg + senior multi Vit daily w Vit D also. I’m 75. After 7 days it is helping.

  3. I am taking OsteoBi-flex 1/d . I have gone thru several bottles but my joints still ache. No swelling and no inflammation. What should I do?

  4. I never tried osteo bi-flex but I see it contain shellfish, I’m allergic to certain shellfish of I use your product would there be a problem

  5. I paid over $157 for 2 bottles, my nurse recommend to me on my 4th day I begin breaking out in whelps head to toe by the 6th day, obviously a allergic reaction to the bi flex was not aware it contained sulfate x 2, I’m allergic to sulfa, quit taking 5 days ago, benedryl dose did not help at all, I’ve scratched til I brought blood. I called customer service explaining my situation, I was advised to go on line to the link for information of money back garantee and there is not info, so I’m out achunck of money and was told to go to doctor, but I’ve not got the $250 deductible on insurance to go, what a rip off..Shame on you, I am a senior citizen and y’all screwed me..

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