Best Natural Nootropics

10 Best Natural Nootropics To Unlock Your True Brain

Written By : David J. Grossklaus   ✓ Fact Checked

In this guide, we are going to reveal the best natural nootropics for boosting your cognition, memory, and focus to get the edge.

(Last Updated on November 9, 2022)

Nootropics are drugs used to enhance cognitive function, including focus, attention, concentration, memory, information processing, learning speed and creativity among others.

Recently, these drugs have gained popularity in the supplement world.

However, they have been traditionally used in Chinese and Ayurvedic medicine for centuries.

They improve mental performance in various ways including increasing blood flow to the brain, protecting neurons from free radical damage, reducing mental fatigue and stimulating brain chemicals.

Nootropics are categorized into 2: synthetic and natural (herbal) nootropics.

Synthetic nootropics are made from chemical compounds and may have side effects such as insomnia, rapid heart rate, anxiety, and insomnia.

Natural nootropics, on the other hand, are made from plant, root, fungi, and herb extracts and are mostly considered safe.

In this article, we evaluate the 10 best natural nootropics and their effect on cognition function.

Read next: 3 Best Brain Enhancement Supplements – Recommended By Experts

Best Natural Nootropics

Bacopa Monnieri

Bacopa Monnieri

Bacopa is an ancient herb in Ayurvedic medicine to enhance cognitive function for a long time.

It is an adaptogenic herb that enhances concentration, memory, and focus while lowering stress levels.

It balances brain chemicals GABA, serotonin, and dopamine and lowers cortisol levels.

Besides, it contains bacosides, active compounds that protect the brain from free radical damage.

Hence, improving neuron communication in the hippocampus, a brain region that plays a crucial role in memory.

A 2014 study 1 shows that Bacopa monnieri improves cognitive function including memory, attention, and information processing.

Rhodiola Rosea

Rhodiola Rosea

Rhodiola Rosea is a popular adaptogen, also known as the golden root or arctic root.

It lowers stress levels by increasing neurotransmitters such as norepinephrine, dopamine, and serotonin.

These neurotransmitters reduce mental fatigue, enhance concentration and accelerate brain energy.

Rhodiola Rosea is an ancient herb used in Chinese, Russian and Scandinavian medicine to reduce fatigue and relax the brain.

Research shows that this herb helps the brain to adapt to stress and lowers symptoms of fatigue, including headaches, muscle soreness and lethargy.

Lion’s mane mushroom

Lion’s mane mushroom

Lion’s mane mushroom is widely used in Chinese medicine to promote nerve growth and protect nerve cells resulting in improved cognitive function.

Besides, it was anciently used to treat neurodegenerative diseases due to its connection to the nerve growth factor.

The nerve growth factor is a neurotrophin that promotes the growth of nerve cells.

But what does science say?

Research shows that this mushroom has anti-inflammatory effects that could reduce symptoms of anxiety and depression.

Besides, it has shown the potential to regenerate brain cells and enhance the function of the hippocampus.

However, these studies have been performed on animals, and there is little research on humans.

In yet another study conducted on rats, lion’s mane mushroom speeds up the recovery time from nervous system injuries by 23 to 41 percent.

Additionally, Lion’s mane mushroom is rich in antioxidants that lower oxidative stress in the brain.


L-Theanine Tea

L-Theanine is an amino acid present in tea.

Studies 2 show that it helps to alleviate stress and anxiety; it stimulates the release of neurotransmitters such as GABA, serotonin, and dopamine, often referred to as the happy hormones.

Also, it boosts alpha-waves in the brain, which is associated with creativity.

Besides, it has been seen to be more effective when stacked with caffeine.

A 2008 study 3 shows that combining caffeine and L-Theanine increases memory, lowers mental fatigue, enhances reaction time, boosts  mental alertness, and improves visual information processing.

Moreover, it reduces the adverse effects of caffeine such as jitteriness.

Ginkgo biloba

Ginkgo biloba

Ginkgo biloba seeds and leaves are used in Chinese medicine for blood circulation and brain function.

But, now modern research focuses on Ginkgo biloba leaves extracts.

This herb is rich in antioxidants –flavonoids and terpenoids that reduce free radical damage.

Thus, it lowers age-related mental decline.

Additionally, it improves blood circulation in the brain, hence, promoting more neuronutrient delivery and removal of toxins.

Ginkgo biloba improves memory, increases attention and focus, and reduces anxiety and dementia symptoms.

Panax Ginseng

Panax Ginseng

Ginseng contains ginsenosides, compounds that protect the brain from free radical damage.

Studies show that ginseng improves mental performance, lowers brain fatigue, and enhances the ability to perform logical problems.

It increases memory through increasing brain neurotransmitters.

What’s more?

It improves brain function in individuals Alzheimer’s disease.

However, research indicates that these benefits may decrease with long term use.


Choline is a nutrient that acts as a vital brain-building block.

It supports attention, memory, brain energy, learning, and brain regeneration.

Choline is a precursor to phosphatidylcholine and acetylcholine in the brain.

Acetylcholine is a neurotransmitter that promotes signaling between neurons in the brain.

Thus, improving better cognition.

On the other hand, Phosphatidylcholine is a significant phospholipid for the cell membrane.

Also, it increases the production of acetylcholine.

Acetylcholine regulates mood, memory, and creativity.

Studies show that phosphatidylcholine improved memory in individuals with Alzheimer’s disease.

Besides, choline promotes fetal brain development during pregnancy.



Caffeine is the most popular psychostimulant drink in the world.

It is found in coffee, cocoa, guarana, tea, energy drinks, and kola nuts.

It is has been proven to improve brain function, including enhancing alertness, concentration, brain energy, and mood.

Caffeine works by inhibiting the release of adenosine, a brain chemical that regulates stimulation.

Also, it stimulates the release of dopamine, which boosts focus, alertness and concentration.

Interestingly, research shows that individuals who take coffee regularly have a lower risk of developing Alzheimer’s and Parkinson’s disease later in life.



Ashwagandha is an adaptogen herb popularly used in Ayurvedic medicine to help the body manage stress and reduce anxiety.

It lowers cortisol levels, especially in chronically stressed individuals.

Besides, it has neuroprotective properties that shield the brain from free radical damage.

A 2014 study shows that Ashwagandha improves memory, learning ability, reaction time, and brain function.



Creatine is an amino acid popular among bodybuilders to boost muscle mass and improve physical performance.

However, creatine a natural nootropic.

It blends with phosphate to form a molecule that stimulates brain energy.

Accelerated brain energy is linked to better reasoning skills and short term memory.


Natural nootropics are effective in boosting brain function; they are considered safe and effective.

However, it is advisable to check with your physician before taking any nootropic to rule out the possibility of side effects.

Natural nootropics are safe alternatives to synthetic nootropics associated with side effects.

They work through boosting resilience against stress, increasing blood flow, preventing free radical damage, and stimulating neurotransmitters.

Besides, these nootropics can be stacked together to boost performance.

Read next: Top 8 Best Brain Boosting Herbs To Support Cognitive Health

Leave a Reply

Your email address will not be published. Required fields are marked *


All MyPill content is medically reviewed or fact checked to ensure that it is as accurate as possible.

We have strict sourcing guidelines and only link to other reputable media sites, educational institutions, and, whenever possible, peer-reviewed studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please contact us through the feedback form on this page.