best cholesterol pills

TOP 5: Best Supplements To Lower Cholesterol Levels Reviews

Written By : David J. Grossklaus   ✓ Fact Checked

MyPill comprised the most comprehensive list of best cholesterol lowering supplements. Click here now!

(Last Updated on November 10, 2023)

Cholesterol, chances are you know the word and have a vague idea of what it is from infomercials on television, and you probably know that too much of it is bad, but that’s about it.

So just what is cholesterol?

Essentially cholesterol is a fat-like substance found in the body that can both be produced by the body, and ingested through food – especially animal products.

When it comes to cholesterol, there two different types, the good type called High Density Lipoprotein Cholesterol or LDL, and the bad type, called Low-Density Lipoprotein Cholesterol or LDL.

In a perfect world, we want to lower the LDL or bad cholesterol.

And while some cholesterol is essential for good health, too much of it can have negative effects on the body in a big way.

Here’s a brief look at the negative effects of too much cholesterol in the body:

  • A buildup of cholesterol in the articles can block blood vessels leading to strokes.
  • A buildup of cholesterol can block blood supply to the heart.
  • Excess cholesterol can build up in the gallbladder and form hard stones.
  • As arteries harden from excess cholesterol, numbness can occur due to low oxygen getting to the limbs.
  • Poor memory can also be caused from excessive cholesterol.

Now if that’s not a wake up call to manage your cholesterol better, I don’t know what is!

And if you haven’t had your levels checked recently, it’s not a bad idea to book a blood test to find out, as 37% of Americans do reportedly have high cholesterol levels.

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And while cholesterol can naturally be lowered to a degree through a healthier diet, it’s a great idea to put an insurance plan in place to put you cholesterol levels back within the healthy levels sooner rather than later.

So what can you do to reduce your cholesterol levels and get your inner health back to 100%?

Supplementing with any of these products in our Best Natural Cholesterol Lowering Supplements list is a terrific start.

We’ve researched all the big brands both online and in-stores to bring you the most comprehensive list, to ensure you get the best results possible, as quick as possible.

Ranking: Best Supplements That Lower Cholesterol Levels






Ingredients Quality




Product Effectiveness




Brand Reputation




1. CholesLo


CholesLo is one of the most effective natural cholesterol lowering supplements we have seen on the market.

Say goodbye to your doctor prescribed drugs which cause more side effects than results, and say hello this naturally derived cholesterol lowering wonder supplement.

CholesLo earned the #1 spot on our list for good reason, it works.

And hundreds of 5 star reviews on their website speak for themselves.

The benefits of CholesLo are life changing, here’s our list benefits you will notices from using this product:

  • Balance out your hormone levels once and for all.
  • Lower your risk of heart disease and stroke significantly.
  • Cleanse and repair your liver.
  • Lower the levels of fatty triglycerides circulating in your blood.
  • Achieve optimal HDL/LDL ratios.

What is it?

This product is a scientifically backed supplement designed to reduce bad cholesterol levels and help restore a healthy balance of HDL and LDL.

Ingredient List

CholesLo is a comprehensive blend of powerful natural ingredients specifically designed to balance your cholesterol levels, and help you achieve optimal inner health.

Specifically, the product is made up of five systems, all which play a role in achieving optimal cholesterol levels and health. the systems are:

  • Lipid Optimizing System: Comprising of Red Yeast Extract, Artichoke Leaf, Phytosterols Complex, Garlic, Pantesin, Co-Q10, Guggulsterones, Policosanol. This Lipid Optimizing System is the backbone of the product, these are the ingredients which are going to directly target lower your lipid and cholesterol levels to help ensure you achieve a health balance of good and bad cholesterol.
  • Liver Cleansing Formula: Comprising of Milk Thistle and N-Acetyl L-Cysteine). The Liver Cleansing Formula is ideal for reducing the risks of gallstones caused by high cholesterol and improving overall liver health.
  • Insulin/Blood-Sugar Regulator: Comprising of R+ Alpha Lipoic Acid. Ideal for improve insulin sensitivity and regulate insulin
  • Inflammation Reducer:  Comprising of Turmeric, Mixed Tocotrienols. This blend is ideal for reducing inflammation both internally and externally and also reducing cortisol.
  • Homocysteine Reducing Formula: Comprising of Vitamin B6, B12, B5 and Folate. This formula designed to reduce the inflammation caused by high levels of homocysteine.

As you can see, the ingredient panel on CholesLo is very well rounded.

Covering all bases from lowering cholesterol to improve heart health, lowering blood sugar and stopping inflammation.

Making it a well deserved winner of our number 1 spot in this list of the best natural cholesterol lowering supplements.

How it works

The unique blend of ingredients in CholesLo are dosed to optimal levels to ensure the highest quality and effectiveness.

The true benefit of CholesLo lies in its ability to restore the balance of good and bad cholesterol via naturally altering certain hormonal patterns.

They point out that “cholesterol problems are primarily caused by a negative change in hormones due to ageing”.

In fact in CholesLo’s 19+ year history they have ran multiple double blind studies, which have all shown significant positive results in as little as 30 days.

2. Nature Made CholestOff

Nature Made CholestOff

CholestOff presents a cost effective solution to high cholesterol that certainly won’t slack on results, and it has hundreds of raving reviews on it’s site to vouch for it.

Here are some of the key benefits of Nature Made CholestOff:

  • Contains ‘Reductol’ a potent proprietary blend to lower LDL.
  • No artificial colours or preservatives.
  • Reduce risks associated with high cholesterol such as heart disease.

What is it?

Nature Made CholestOff is a highly dosed cholesterol lowering supplement designed to lower LDL ‘bad cholesterol’ to improve your quality of life and reduce the risks of high cholesterol related illness.

Ingredient List

The sole ingredient in CholestOff is a massive 900 mg dosage of plant sterols/stanols.

How it works

CholestOff’s singular ingredient is a combination of plant sterols and stanols.

This potent combination is clinically proven to help lower LDL the bad cholesterol and even out the balance for overall general health.

Plant sterols are essentially the plant version of the cholesterol you would ingest from animal products, but help lower cholesterol rather than increase it.

Studies of individuals with high cholesterol supplementing with plant sterols indicated a drop in cholesterol of 13% in a 6 month period, which shows the true power of this supplement.

3. HPF Cholestene Red Yeast Rice

HPF Cholestene Red Yeast Rice

Unlike the first two supplements in this list, HPF Cholestene utilises red yeast extract a potent natural extract shown to lower LDL cholesterol in as little as four weeks.

So what can you expect from supplementing like HPF Cholestene?

  • Lowered LDL bad cholesterol.
  • Reduced inflammation.
  • Improved heart function.
  • Improve some metabolic syndromes.
  • May be helpful for fighting obesity.

What is it?

HPF Cholestene is a 100% natural red yeast extract supplement which is often used to treat high cholesterol by lowering the levels of LDL cholesterol in your body

Research has shown that red yeast extract can also have a whole host of other benefits to improving your longevity and general health.

HPF is a tried and tested brand with numerous products on the market and several hundred 5 star reviews on their website, so when you pick up anything from HCF, you know you are getting quality.

Ingredient List

HPF Cholestene contains the sole ingredient Red Yeast Rice in an efficacious 1200 mg dosing so users should have terrific results using this supplement as directed on the bottle, or as prescribed from their doctor.

How it works

For a single ingredient, Red Rice Yeast has many benefits. When it comes to lowering cholesterol, it goes above and beyond most other natural ingredients.

The reason behind why this supplement is so effective is that it contains Monacolin K also known as Lovastatin which has been shown to lower cholesterol and lower your risk of heart attacks, strokes and atherosclerosis.

But the benefits of this supplement don’t end there.

Red Yeast Extract has been shown to lower to lower blood cholesterol parameters, liver enzymes and leptin levels which can further lower cholesterol and may have improved effects on weight loss in obesity.

Finally, it has been linked to lowering the risk of heart attack, and mortality from heart attack by improving blood vessel flexibility and lowers blood vessel stiffness in higher cholesterol humans.

All those awesome health benefits from one simple supplement!

4. Genius Heart & Cardiovascular

Genius Heart & Cardiovascular

This is a potent supplement that combines some of the more beneficial ingredients found in the previous three supplements, making it a well rounded cholesterol lowering health supplement.

There are numerous benefits from Genius Heart & Cardiovascular, and as the name of the product suggests, it’s more than just a cholesterol lowering supplement.

From supplementing with Genius Heart & Cardiovascular you can expect:

  • Improved blood pressure readings.
  • Improved cardiovascular endurance through improved oxygen supply.
  • Reduced risk of cardiovascular disease.
  • Improved blood flow to organs and muscles.
  • Lower cholesterol levels once and for all!

What is it?

Genius Heart & Cardiovascular is a well formulated supplement with optimal dosages of each ingredient.

This product is an all in one inner health supplement which will help promote healthy blood pressure, cholesterol levels, while increasing cognitive function, cellular energy and joint health.

Making it an ideal supplement for many adults who are in need of better internal health.

Ingredient List

Genius Heart & Cardiovascular combines four proven ingredients in high dosages for maximal results each serving of this product contains:

  • Pantesin Pantethine (Coenzyme A Precursor): This ingredient is paramount for healthy cardiovascular function and supporting healthy lipid levels.
  • Mega Natural BP Grape Seed Extract: This ingredient can help lower blood pressure, improve heart health and prevent cognitive decline.
  • MicoActive CoQ10: One of the most tried and tested ingredients for reducing oxidative stress, reducing tissue damage and Improving heart health.
  • MenaQ7 Vitamin K2: Prevents blood clotting, and contributes to healthy heart and immune system.

So as you can see, Genius Heart & Cardiovascular is loaded full of great ingredients to not only improve your cholesterol, but to help improve your overall internal wellness.

How it works

The primary ingredient for reducing cholesterol which is the focus or the article is Pantesin.

This ingredient works by balancing out the levels of good and bad cholesterol levels in the body to providing safe and effective support for the heart.

However while Pantesin is the only ingredient which will directly affect cholesterol levels, it’s important to note that many of the other ingredients will also have this effect by default, from increasing heart health, or promoting blood flow.

Which means the products ingredients all work synergistically to lower cholesterol and improve health.

5. Heart Savior

Heart Savior

Heart Saviour is a dietary supplement that lowers cholesterol and promotes heart health.

It does this by using a combination of potent ingredients with scientifically proven benefits.

These ingredients attack cholesterol from 6 distinct ways.

The manufacturer claims that it is the most comprehensive heart health product in the market.

Heart Saviour was formulated as an alternative to cholesterol prescription drugs that carry adverse side effects.

As an alternative, it is quite safe to use as it is made from natural ingredients.

For best results, it is recommended that you take two capsules in the morning and two capsules in the evening with a meal.

You should not take this supplement if you are under 18 years, expectant or nursing.

Most importantly, Heart Saviour should not be combined with other statin drugs or other cholesterol-lowering medication.

Heart Saviour is manufactured by New Health Corp, a supplements company based in North Carolina, USA.

How it works?

Heart Saviour relies on several ingredients to bring you the following benefits:

  • Lower cholesterol levels.
  • Promote heart health.
  • Reduce inflammation in the arteries.
  • Lower C Reactive protein levels.


Here are three main ingredients in this cholesterol-lowering supplement that make it so effective:

  • Coenzyme Q10 – This coenzyme is responsible for cell function. CoQ10 levels in the body decrease with age but is particularly low in people suffering from certain conditions such as cancer, heart problems, HIV and diabetes. Increasing C0Q10 supplements can raise its levels in the body. Proper levels promote efficiency in heart and muscle cells.
  • Red Yeast Rice – Red Yeast Rice is made by fermenting rice with a yeast called Monascus purpureus. It has been used as medicine in China for many centuries. The ancient Chinese used it to boost blood circulation, stimulate the spleen and to soothe stomach upsets. In this fermented state red yeast rice contains substances called monacolins that inhibit the production of cholesterol in the body.
  • Niacin – Niacin is used to reduce high blood pressure and improve blood cholesterol levels. This is because it can improve lipid profiles for LDL cholesterol. A form of Niacin known as Inositol Hexanicotinate or ‘Flush Free Niacin’ has been seen to increase HDL levels (good cholesterol) by up to 30% 1.

Tips For Buying Natural Cholesterol Lowering Products Online

high cholesterol treatment

So, now that you have read through our comprehensive list, the question remains, how do you find the best product for you online?

The answer for this is simple really, and it’s going to depend on what you specifically need the product for.

If you are looking for a product solely to lower your cholesterol ASAP, all to the products in our top 4 list will work wonders.

However, if you need something a little more comprehensive, such as a product that will support brain and heart function a better choice for you may be Genius Heart & Cardiovascular or CholesLo, both of which offer a wide range of health benefits that go above and beyond simply levelling out your cholesterol levels.

We also believe it’s paramount that whenever you purchase any cholesterol lowering supplement online you follow the following steps:


Always shop from trusted sites, you can rest assured that any site that you visit which is recommended in our articles will be 100% safe and trusted.

However there are websites out there which aren’t as trustworthy and may provide misinformation, so make sure you check customer reviews, order count and where the website is based or where it ships its products from.

Check With Your Doctor

Always consult with your doctor, especially prior to taking any supplement which is designed to aid serious conditions involving the heart or cholesterol.

While all the products listed are safe for the general population it’s best to have peace of mind that they won’t interact with other medications you may be on.

Look for Deals

All of the websites we have listed throughout the article are absolutely loaded with awesome deals on their products. Some of these may be flat discounts, multi-purchase savings or free shipping.

The moral is, always bargain hunt – you can save plenty while still getting awesome products!

Optimise Your Results

If you visited your doctor before purchasing any of these supplements, they would have recommended that there are several ways that you can lower your cholesterol without supplements.

And they are correct!

There’s a whole host of ways you can optimise your results, and if you do them in conjunction with a supplement such as the ones listed about, your bound to get awesome results and have healthy cholesterol levels in no time.

You can optimise your results by following these simple lifestyle change steps:

Opt for Heart Healthy Foods

It’s no secret the some foods are considered good for the heart and others are considered bad. But what’s the difference between them?

Well heart healthy foods are going too include things such as healthy fats like avocado, and nuts.

Increasing the amount of omega 3 oils from sources such a fish and increasing fibre to your diet!

Cut Out The Junk

Well, you can eat junk sometimes.

But to achieve lifelong healthy cholesterol levels, you really need to tone down the amount of saturated fats and trans fats your consuming in your diet.

These are a one way ticket to high LDL.

Increase Your Exercise

Exercise can increase HDL cholesterol, which is the good kind.

Aim for 30 minutes of exercise 5 days a week.

If you can’t manage that, start small and work your way up over time in your free time.

It could be things as simple as walking, playing sport or riding your bike to work.

Lose Weight

Higher weight generally increases your risk of everything bad associated with poor health, having too much excess fat weight can put strain on your body and force it to work over time.

Research has shown that reducing your weight by as little as 5-10% can improve cholesterol levels.

Stop Smoking

The benefits of quitting smoking are exceptional to say the least, you can expect to live longer, have greater endurance, and feel more energetic to begin with.

Quitting smoking can also help reduce your cholesterol and blood pressure at high rates.

FAQ (Frequently Asked Questions)

What is a cholesterol-lowering supplement?

A cholesterol-lowering supplement is a dietary supplement that is designed to lower cholesterol levels in the blood.

The majority of cholesterol-lowering supplements contain ingredients that either increase the rates of HDL (good cholesterol) in the blood or reduce the amounts of LDL (bad cholesterol) in the blood.

What are some of the benefits of cholesterol-lowering supplements?

Some of the benefits of cholesterol-lowering supplements include:

  • Lowering the levels of ‘bad’ cholesterol in the body.
  • Improving heart health and functionality.
  • Reducing inflammation in the arteries.
  • They support healthy blood pressure levels.
  • Some boost brain health.

Who should use cholesterol-lowering supplements?

People who have high cholesterol levels should consider taking cholesterol-lowering supplements.

This is because they are at high risk of associated health issues such as heart disease and stroke.

Older people should also consider taking cholesterol-lowering supplements.

This is because the possibility of heart problems increases with age.

The production of Coenzyme Q10, which is responsible for cell function, decreases with age.

This reduces the functionality of the heart and muscle cells.

Taking a supplement with C0Q10 can boost cell function in the heart.

It is important to note that high cholesterol does not have any specific symptoms.

As such, even people who think that they might not have high cholesterol levels might do.

Doctors recommend that anyone above the age of 20 years have their cholesterol levels checked at least once every five years.

Which ingredients should I expect to see in a cholesterol-lowering supplement?

Ingredients vary widely between cholesterol-lowering supplements, but you should look out for the following in a good supplement:

  • Red Yeast Rice.
  • Coenzyme Q10.
  • Niacin.
  • Grape seed extract.
  • Alpha Lipoic Acid.
  • Omega 3 Fish Oil.
  • Green tea extract.
  • Plant sterols.
  • Flax seeds.

How can I decide which cholesterol-lowering supplement to use?

The first thing to consider when choosing a cholesterol-lowering supplement is the type of cholesterol that it will work on.

Most supplements work by either lowering the levels of ‘bad cholesterol,’ that is LDL or increasing the levels of ‘good cholesterol’ that is HDL.

Bad cholesterol causes build up in the arteries, reducing blood flow.

This may cause a heart attack.

Another factor to consider is the ingredients in the supplement.

Some supplements like HPF Cholestene contain only one active ingredient, while others contain multiple components.

It is important to weigh which ingredients are effective and also in what quantities.

Cost is also an important factor.

Our review has revealed that supplements sold at multiple stores have different pricing depending on the store.

For example, a 30-day supply of Heart Saviour costs $ 39.95 on the official website and $ 27.97 on Amazon, at the time of this review.

Other factors to consider include accessibility, dosage, and taste.

What are the side effects of cholesterol-lowering supplements?

Most cholesterol-lowering supplements are made from natural ingredients and thus do not have adverse side effects.

There could be some isolated cases however based on the ingredients used in a supplement.

Common issues that may arise include bloating, abdominal discomfort, constipation, diarrhea and gas.

These issues should be minor however, and if any persists, you should consider stopping and possibly seeing a doctor.

Most cholesterol-lowering supplements warn against combining the supplements with other prescription drugs.

Naturally, you should not take these supplements if you are expectant or nursing.

Should I combine a gym workout with cholesterol-lowering supplements?

Yes, you should. Eating a balanced diet and being physically active can contribute highly to lowering your cholesterol levels.

Some supplements, such as HPF Cholestene, are designed to work in conjunction with a good exercise program.

Exercise has been proven to increase the levels of good cholesterol in the blood.

Lower cholesterol also has the direct effect of improving heart health.


So, now you have all the information you need at your disposal to get your cholesterol levels under control once and for all.

We believe it all comes down to making smarter choices in your day to day life.

Combine a great supplement like the ones listed in our article, with some easy to incorporate lifestyle changes and you will be well on your way to achieving a healthier life in no time!

Do you have any feedback on CholesLo, Nature Made CholestOff, HPF Cholestene Red Yeast Rice or Genius Heart & Cardiovascular?

Maybe you’ve tried them before and had awesome results?

Leave the team a comment below and let us know!

3 Replies to TOP 5: Best Supplements To Lower Cholesterol Levels Reviews

  1. CholestOff dosage is four tabs 2x daily, therefore, the bottle of 60 tabs is NOT a two month supply as you state in your article. However it works. Dropped my LDL by ten points down into the normal level.

  2. Is there a free sample bottle I can try. My doctor’s written prescriptions of several statins resulted in muscle cramps. I do not like taking any medications but some appear to be necessary to the diagnosis.

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